CDC lipoxygenase inhibitor
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 500mg | $1250 | Check With Us |
| 1g | $1950 | Check With Us |
| 5g | $4935 | Check With Us |
: Cat #: V2397 CAS #: 132465-11-3 Purity ≥ 99%
Description: CDC(Cinnamyl-3,4-dihydroxy-α-cyanocinnamate) lipoxygenase inhibitor is a novel ,potent and direct inhibitor of 5-LO (5-Lipoxygenase),12-LO and 15-LO.
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| Molecular Weight (MW) | 321.33 |
|---|---|
| Molecular Formula | C19H15NO4 |
| CAS No. | 132465-11-3 |
| SMILES Code | O=C(OC/C=C/C1=CC=CC=C1)/C(C#N)=C/C2=CC=C(O)C(O)=C2 |
| Synonyms | CDC 5-LO inhibitor; Cinnamyl-3,4-dihydroxy-α-cyanocinnamate; |
| Protocol | In Vitro | High glucose or 12(S)-HETE remarkably increased transendothelial dextran transport, and in combination it was increased further. Addition of the 12/15-LO inhibitor, CDC, partially suppressed dextran transport. |
|---|---|---|
| In Vivo | The high glucose and 12(S)-hydroxyeicosatetraenoic acid (HETE) could alter vascular endothelial (VE)-cadherin and β‐catenin phosphorylation levels, but did not alter total protein expression. However, the 12/15-LO inhibitor, Cinnamyl-3,4-dihydroxy-α-cyanocinnamate (CDC), antagonized the effect of high glucose on protein phosphorylation to mitigate destruction of the endothelial cell barrier, and the mouse diabetes mellitus model further confirmed these conclusions. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.1121 mL | 15.5603 mL | 31.1207 mL | 62.2413 mL |
| 5mM | 0.6224 mL | 3.1121 mL | 6.2241 mL | 12.4483 mL |
| 10mM | 0.3112 mL | 1.5560 mL | 3.1121 mL | 6.2241 mL |
| 20mM | 0.1556 mL | 0.7780 mL | 1.5560 mL | 3.1121 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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Volume
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Molecular Weight*
The dilution calculator equation
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Volume(start)
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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V1
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.