Vonafexor
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $1750 | Check With Us |
| 200mg | $2625 | Check With Us |
| 500mg | $4430 | Check With Us |
: Cat #: V2180 CAS #: 1192171-69-9 Purity ≥ 98%
Description: Vonafexor (EYP001) is a novel selective FXR agonist with anti-HBV effects.
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- Related Biological Data
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| Molecular Weight (MW) | 489.76 |
|---|---|
| Molecular Formula | C19H15Cl3N2O5S |
| CAS No. | 1192171-69-9 |
| SMILES Code | O=C(C(O1)=CC2=C1C=CC(N3CCN(S(=O)(C4=C(Cl)C=CC=C4Cl)=O)CC3)=C2Cl)O |
| Synonyms | Vonafexor; EYP001; EYP-001; EYP 001; |
| Protocol | In Vitro | Vonafexor (EYP001) inhibits the HBV replication cycle in HepaRG cells resulting in significant reductions in HBV DNA, HBsAg and HBeAg secretion, with additive effects when combined with Entecavir (HY-13623) or Tenofovir (HY-13910). |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.0418 mL | 10.2091 mL | 20.4182 mL | 40.8363 mL |
| 5mM | 0.4084 mL | 2.0418 mL | 4.0836 mL | 8.1673 mL |
| 10mM | 0.2042 mL | 1.0209 mL | 2.0418 mL | 4.0836 mL |
| 20mM | 0.1021 mL | 0.5105 mL | 1.0209 mL | 2.0418 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.