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Fondaparinux sodium

This product is for research use only, not for human use. We do not sell to patients.

Fondaparinux sodium
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Size Price Stock
100mg$700Check With Us
200mg$1050Check With Us
500mg$1770Check With Us
email: [email protected]        [email protected]

Cat #: V21240 CAS #: 114870-03-0 Purity ≥ 98%

Description: Fondaparinux sodium (PENTA; SR-90107A; IC-85158; Arixtra; Xantidar) is a factor Xa inhibitor to form the high affinity binding site for the anti-coagulant factor antithrombin III (ATIII).

References: Bauer KA. et al. Fondaparinux sodium: a selective inhibitor of factor Xa. Am J Health Syst Pharm. 2001 Nov 1;58 Suppl 2:S14-7.

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Molecular Weight (MW)1728.08
Molecular FormulaC31H43N3Na10O49S8
CAS No.114870-03-0
SMILES CodeO[C@H]1[C@@H]([C@H](O[C@@]([H])([C@@H]1NS([O-])(=O)=O)O[C@@H]2[C@H](O[C@]([H])([C@@H]([C@H]2O)O)O[C@H]3[C@@H]([C@H]([C@H](O[C@@H]3COS([O-])(=O)=O)O[C@@]4([C@@H](O[C@H]([C@@H]([C@H]4O)OS([O-])(=O)=O)O[C@]5([C@@H]([C@H]([C@H](O[C@@H]5COS([O-])(=O)=O)OC)NS([O-])(=O)=O)O)[H])C([O-])=O)[H])NS([O-])(=O)=O)OS([O-])(=O)=O)C([O-])=O)COS([O-])(=O)=O)O.[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+]
SynonymsFondaparinux sodium; Fondaparinux sodium salt; PENTA; Arixtra; Xantidar; SR 90107A; IC-85158; SR-90107A; SR90107A; IC 85158; IC85158;
ProtocolIn VitroFondaparinux sodium is the first agent of a new class of anticoagulants that selectively target factor Xa. For Fondaparinux, its IC50 values (anti-Xa IU/ml) are 0.59±0.05 for activated monocytes (ac-M) and 0.17±0.03 for monocyte-derived microparticles (MMPs).
In VivoFondaparinux sodium has a linear, dose-dependent pharmacokinetic profile, which provides a highly predictable response. Fondaparinux sodium is 100% bioavailable, has a rapid onset of action, and has a half-life of 14 to 16 hours, allowing for sustained antithrombotic activity over a 24-hour period. The drug does not affect prothrombin time or activated partial thromboplastin time, nor does it affect platelet function or aggregation.
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM0.5787 mL2.8934 mL5.7868 mL11.5735 mL
5mM0.1157 mL0.5787 mL1.1574 mL2.3147 mL
10mM0.0579 mL0.2893 mL0.5787 mL1.1574 mL
20mM0.0289 mL0.1447 mL0.2893 mL0.5787 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.