Tamibarotene

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
2g	$550	Check With Us
5g	$950	Check With Us
10g	$1425	Check With Us

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Cat #: V0946 CAS #: 94497-51-5 Purity ≥ 98%

Description: Tamibarotene (formerly SY-1425; SY1425; Am 80; Retinobenzoic acid, Amnoid, AMNOLAKE) is a novel, potent, orally bioavailable, and synthetic retinoic acid receptor (RAR) agonist with potential anticancer activity against AML-acute promyelocytic leukaemia.

References: Wang X, et al. Retinoic acid receptor alpha drives cell cycle progression and is associated with increased sensitivity to retinoids in T-cell lymphoma. Oncotarget. 2017 Apr 18;8(16):26245-26255.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	351.44
Molecular Formula	C22H25NO3
CAS No.	94497-51-5
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 70 mg/mL (199.2 mM)r
	Water: <1 mg/mLr
	Ethanol: 70 mg/mL (199.2 mM)
SMILES Code	O=C(O)C1=CC=C(C(NC2=CC=C3C(C)(C)CCC(C)(C)C3=C2)=O)C=C1
Synonyms	SY-1425; Am80, SY 1425; Am 80, SY1425; Retinobenzoic acid, Amnoid, AMNOLAKE, Am-80;

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.8454 mL	14.2272 mL	28.4544 mL	56.9087 mL
5mM	0.5691 mL	2.8454 mL	5.6909 mL	11.3817 mL
10mM	0.2845 mL	1.4227 mL	2.8454 mL	5.6909 mL
20mM	0.1423 mL	0.7114 mL	1.4227 mL	2.8454 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.