PF-06840003
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $500 | Check With Us |
| 500mg | $829 | Check With Us |
| 1g | $1245 | Check With Us |
: Cat #: V3270 CAS #: 198474-05-4 Purity ≥ 98%
Description: PF-06840003 (also known as PF06840003; EOS200271) is a highly potent and selective, orally bioavailable IDO-1 inhibitor (IC50 of 0.15 μM) with anticancer activity.
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- Physicochemical and Storage Information
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| Molecular Weight (MW) | 232.21 |
|---|---|
| Molecular Formula | C12H9FN2O2 |
| CAS No. | 198474-05-4 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: ≥ 28 mg/mLr |
| Water: NAr | |
| Ethanol: NA | |
| SMILES Code | O=C(C(C1=CNC2=C1C=C(F)C=C2)C3)NC3=O |
| Synonyms | PF-06840003; EOS200271, PF 06840003; EOS-200271; PF06840003; EOS 200271 |
| Protocol | In Vitro | PF-06840003 reverses IDO-1-induced T-cell anergy in vitro. |
|---|---|---|
| In Vivo | PF-06840003 reduces intratumoral kynurenine levels in mice by >80% and inhibits tumor growth in multiple preclinical syngeneic models in mice, in combination with immune checkpoint inhibitors. PF-0684003 has favorable predicted human pharmacokinetic properties, including a predicted t1/2 of 16-19 hours. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 4.3064 mL | 21.5322 mL | 43.0645 mL | 86.1289 mL |
| 5mM | 0.8613 mL | 4.3064 mL | 8.6129 mL | 17.2258 mL |
| 10mM | 0.4306 mL | 2.1532 mL | 4.3064 mL | 8.6129 mL |
| 20mM | 0.2153 mL | 1.0766 mL | 2.1532 mL | 4.3064 mL |
The molarity calculator equation
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The dilution calculator equation
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.