8-Nitrotryptanthrin
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $2080 | Check With Us |
| 500mg | $2980 | Check With Us |
| 1g | $4470 | Check With Us |
: Cat #: V2811 CAS #: 77603-42-0 Purity ≥ 98%
Description: 8-Nitrotryptanthrin is a potent selective inhibitor of the human indoleamine 2,3-dioxygenase 2 (hIDO2) which dramatically reduces IDO2 activity with Ki value of 0.97 μM.
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| Molecular Weight (MW) | 293.23 |
|---|---|
| Molecular Formula | C₁₅H₇N₃O₄ |
| CAS No. | 77603-42-0 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 6.4 mg/mL (Need warming)r |
| Water:r | |
| Ethanol: | |
| Solubility In Vivo | 8-Nitrotryptanthrin; 8-Nitro tryptanthrin |
| SMILES Code | O=C1N2C(C(C3=C2C=CC([N+]([O-])=O)=C3)=O)=NC4=CC=CC=C41 |
| Synonyms | 8-Nitrotryptanthrin, GNF-PF-3777 |
| Protocol | In Vitro | The typtanthrin derivative GNF-PF-3777 (8-Nitrotryptanthrin; Compound 5i) is found to be a potent hIDO2 inhibitor with superior efficiency far better than that of the most frequently-used inhibitor L-1-MT. The IC50 values show that all nine tryptanthrin compounds display hIDO2 inhibitory activities, GNF-PF-3777 demonstrates much stronger inhibition (1.87 μM) than both L-1-MT (82.53 μM) and D-1-MT (262.75 μM). GNF-PF-3777 exhibits significant antitrypanosomal activity with EC50 of 0.82 μM. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.4103 mL | 17.0515 mL | 34.1029 mL | 68.2058 mL |
| 5mM | 0.6821 mL | 3.4103 mL | 6.8206 mL | 13.6412 mL |
| 10mM | 0.3410 mL | 1.7051 mL | 3.4103 mL | 6.8206 mL |
| 20mM | 0.1705 mL | 0.8526 mL | 1.7051 mL | 3.4103 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start)
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Volume(start)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
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V1
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.