Gedatolisib (PF05212384, PKI587)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 500mg | $829 | Check With Us |
| 1g | $1280 | Check With Us |
| 5g | $3240 | Check With Us |
: Cat #: V0128 CAS #: 1197160-78-3 Purity ≥ 98%
Description: Gedatolisib (also called PF-05212384, PKI-587) is a novel, highly potent dual inhibitor of PI3Kα, PI3Kγ and mTOR with potential anticancer activity.
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- Physicochemical and Storage Information
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- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 615.73 |
|---|---|
| Molecular Formula | C32H41N9O4 |
| CAS No. | 1197160-78-3 |
| Storage | -20℃ for 3 years in powder form;r |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 2 mg/mL (3.24 mM)r |
| Water:<1 mg/mLr | |
| Ethanol: <1 mg/mL | |
| SMILES Code | O=C(NC1=CC=C(C2=NC(N3CCOCC3)=NC(N4CCOCC4)=N2)C=C1)NC5=CC=C(C(N6CCC(N(C)C)CC6)=O)C=C5 |
| Synonyms | PKI587; PKI-587; PKI 587; PF05212384; PF-05212384; PF 05212384; PF5212384; PF-5212384; PF 5212384; Gedatolisib |
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.6241 mL | 8.1204 mL | 16.2409 mL | 32.4818 mL |
| 5mM | 0.3248 mL | 1.6241 mL | 3.2482 mL | 6.4964 mL |
| 10mM | 0.1624 mL | 0.8120 mL | 1.6241 mL | 3.2482 mL |
| 20mM | 0.0812 mL | 0.4060 mL | 0.8120 mL | 1.6241 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.