GSK1059615 | CAS 958852-01-2

GSK1059615

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
250mg	$980	Check With Us
500mg	$1420	Check With Us
1g	$2130	Check With Us

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Cat #: V0126 CAS #: 958852-01-2 Purity ≥ 98%

Description: GSK1059615 is a novel, potent and reversible inhibitor of P13K (phosphatidylinositol-3-kinases) with potential anticancer activity.

References: Carnero A. Novel inhibitors of the PI3K family. Expert Opin Investig Drugs. 2009 Sep;18(9):1265-77.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	333.36
Molecular Formula	C18H11N3O2S
CAS No.	958852-01-2
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solve
Solubility In Vitro	DMSO: 2 mg/mL (6.0 mM)r
	Water:<1 mg/mLr
	Ethanol: <1 mg/mL
SMILES Code	O=C(N/C1=C/C2=CC=C3N=CC=C(C4=CC=NC=C4)C3=C2)SC1=O
Synonyms	GSK1059615; GSK-1059615; GSK-1059615

Protocol	In Vitro	GSK1059615 inhibits PI3Kα, β, γ and δ, with Ki of 0.42 nM, 0.6 nM, 0.47 nM and 1.7 nM, respectively.
Protocol	In Vivo	GSK1059615 (25 mg/kg) effectively inhibits tumor growth in xenograft mice models of BT474 or HCC1954 breast cancer cells.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.9998 mL	14.9988 mL	29.9976 mL	59.9952 mL
5mM	0.6000 mL	2.9998 mL	5.9995 mL	11.9990 mL
10mM	0.3000 mL	1.4999 mL	2.9998 mL	5.9995 mL
20mM	0.1500 mL	0.7499 mL	1.4999 mL	2.9998 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.

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