Fluorofenidone (AKF-PD; AKFPD)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
100mg	$430	In Stock
250mg	$750	In Stock
500mg	$1125	In Stock

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Cat #: V19873 CAS #: 848353-85-5 Purity ≥ 98%

Description: Fluorofenidone(AKF-PD; AKFPD), a derivative of AMR69, a promising multifunctional antifibrosis pyridinone drug which act as a potent inhibitor of nicotinamide adeninedinucleotide phosphate oxidase via PI3K/Akt pathway in the pathogenesis of renal interstitial fibrosis.

References: Qin J, et al. Fluorofenidone inhibits nicotinamide adeninedinucleotide phosphate oxidase via PI3K/Akt pathway in the pathogenesis of renal interstitial fibrosis. Nephrology (Carlton). 2013 Oct;18(10):690-9.

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Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	203.21
Molecular Formula	C12H10FNO
CAS No.	848353-85-5
SMILES Code	O=C1C=CC(C)=CN1C2=CC=CC(F)=C2
Synonyms	Fluorofenidone

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	4.9210 mL	24.6051 mL	49.2102 mL	98.4204 mL
5mM	0.9842 mL	4.9210 mL	9.8420 mL	19.6841 mL
10mM	0.4921 mL	2.4605 mL	4.9210 mL	9.8420 mL
20mM	0.2461 mL	1.2303 mL	2.4605 mL	4.9210 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.