SAR-405
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1450 | To Be Confirmed |
| 500mg | $2080 | To Be Confirmed |
| 1g | $3120 | To Be Confirmed |
: Cat #: V4833 CAS #: 1523406-39-4 Purity ≥ 98%
Description: SAR405 (SAR-405) is a novel, potent and selective PIK3C3/Vps34 inhibitor (IC50 = 1.2 nM) with anticancer activity.
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- Related Biological Data
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| Molecular Weight (MW) | 443.85 |
|---|---|
| Molecular Formula | C19H21ClF3N5O2 |
| CAS No. | 1523406-39-4 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| SMILES Code | O=C1C=C(N2[C@H](C)COCC2)N=C3N(CC4=CC(Cl)=CN=C4)[C@H](C(F)(F)F)CCN31 |
| Synonyms | SAR 405; SAR-405; SAR405; |
| Protocol | In Vitro | The activity of SAR405 is next evaluated on a dedicated Vps34 cellular assay using a GFP-FYVE–transfected HeLa cell line. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.2530 mL | 11.2651 mL | 22.5301 mL | 45.0603 mL |
| 5mM | 0.4506 mL | 2.2530 mL | 4.5060 mL | 9.0121 mL |
| 10mM | 0.2253 mL | 1.1265 mL | 2.2530 mL | 4.5060 mL |
| 20mM | 0.1127 mL | 0.5633 mL | 1.1265 mL | 2.2530 mL |
The molarity calculator equation
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The dilution calculator equation
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Volume(start)
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.