Dactolisib tosylate

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
1g	$470	Check With Us
2g	$680	Check With Us
5g	$1150	Check With Us

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Cat #: V4263 CAS #: 1028385-32-1 Purity ≥ 98%

Description: Dactolisib tosylate (formerly also known as NVP-BEZ235 tosylate and BEZ-235 tosylate) is an ATP-competitive and dual inhibitor of PI3K (phosphatidylinositol 3-kinase) and mTOR for p110α/γ/δ/β and mTOR(p70S6K) with IC50 of 4 nM /5 nM /7 nM /75 nM /6 nM in cell-free assays, respectively.

References: Maira SM, et al. Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity. Mol Cancer Ther, 2008, 7(7), 1851-1863.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	641.75
Molecular Formula	C37H31N5O4S
CAS No.	1028385-32-1
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: >30 mg/mLr
	Water: N/Ar
	DMF: N/A
Solubility In Vivo	NMP+polyethylene glycol 300 (10/90, v/v): 30 mg/mL
SMILES Code	CC(C1=CC=C(N(C2=C3C=NC4=CC=C(C5=CC6=CC=CC=C6N=C5)C=C24)C(N3C)=O)C=C1)(C)C#N.O=S(C7=CC=C(C)C=C7)(O)=O
Synonyms	BEZ235 Tosylate; NVP-BEZ 235 Tosylate; Dactolisib tosylate; NVP-BEZ235-ANA; UNII-U54GT9151S;

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	1.5582 mL	7.7912 mL	15.5824 mL	31.1648 mL
5mM	0.3116 mL	1.5582 mL	3.1165 mL	6.2330 mL
10mM	0.1558 mL	0.7791 mL	1.5582 mL	3.1165 mL
20mM	0.0779 mL	0.3896 mL	0.7791 mL	1.5582 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.