AS-605240
This product is for research use only, not for human use. We do not sell to patients.
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| Size | Price | Stock |
|---|---|---|
| 500mg | $728 | Check With Us |
| 1g | $1190 | Check With Us |
| 5g | $3010 | Check With Us |
: Cat #: V0115 CAS #: 648450-29-7 Purity ≥ 98%
Description: AS-605240 is a novel, potent, orally bioactive and ATP-competitive inhibitor of PI3-kinase γ (PI3Kγ) with potential anti-inflammatory activity.
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| Molecular Weight (MW) | 257.27 |
|---|---|
| Molecular Formula | C12H7N3O2S |
| CAS No. | 648450-29-7 |
| SMILES Code | O=C(NC/1=O)SC1=C\C2=CC=C3N=CC=NC3=C2 |
| Synonyms | AS 605240; AS605240; AS-605240 |
| Protocol | In Vitro | AS-605240 is an isoform-selective inhibitor of PI3Kγ with over 30-fold selectivity for PI3Kδ and β, and 18- and 7.5-fold selectivity over PI3Kα, respectively. AS-605240 shows an inhibitory effect on C5a-mediated PKB phosphorylation in RAW264 mouse macrophages with an IC50 of 0.09 μM. AS-605240 blocks PKB phosphorylation induced by MCP-1 and has little or no effect after stimulation with CSF-1. AS-605240 inhibits MCP-1-mediated phosphorylation of PKB and its downstream substrates GSK3α and β in a concentration-dependent manner. AS605240 suppresses in a dose-dependent manner the proliferation of BDC2.5 CD4+ T cells. |
|---|---|---|
| In Vivo | AS-605240 (30 mg/kg BW, per os, every 12 h) markedly decreases FoxM1 expression in mouse lungs and fails to restore vascular integrity. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.8870 mL | 19.4348 mL | 38.8697 mL | 77.7393 mL |
| 5mM | 0.7774 mL | 3.8870 mL | 7.7739 mL | 15.5479 mL |
| 10mM | 0.3887 mL | 1.9435 mL | 3.8870 mL | 7.7739 mL |
| 20mM | 0.1943 mL | 0.9717 mL | 1.9435 mL | 3.8870 mL |
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The dilution calculator equation
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.