Duvoglustat hydrochloride

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
100mg	$900	Check With Us
200mg	$1350	Check With Us
500mg	$2280	Check With Us

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Cat #: V20309 CAS #: 73285-50-4 Purity ≥ 99%

Description: Duvoglustat hydrochloride (1-Deoxynojirimycin; AT-2220; Moranoline; deoxynojirimycin; DNJ) is a novel and potent alpha-glucosidase inhibitor found in mulberry leaves and has antihyperglycemic, anti-obesity, and antiviral activities.

References: Gao K, et al. 1-Deoxynojirimycin: Occurrence, Extraction, Chemistry, Oral Pharmacokinetics, Biological Activities and In Silico Target Fishing. Molecules. 2016 Nov 23;21(11). pii: E1600.

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Physicochemical and Storage Information
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Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	199.63
Molecular Formula	C6H14ClNO4
CAS No.	73285-50-4
SMILES Code	O[C@@H]1[C@@H](CO)NC[C@H](O)[C@H]1O.[H]Cl
Synonyms	AT2220; AT-2220; AT 2220; Moranoline; Moranolin; DNJ; Duvoglustat. BAY-h 5595; 1DNJ; NOJ; Duvoglustat hydrochloride; 1-Deoxynojirimycin; 1-Deoxy-Nojirimycin; deoxynojirimycin;

Protocol	In Vitro	1-Deoxynojirimycin hydrochloride (Duvoglustat hydrochloride) (20-80 mg/kg; i.v.; daily for four weeks) shows anti-obesity effect.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	5.0093 mL	25.0463 mL	50.0927 mL	100.1853 mL
5mM	1.0019 mL	5.0093 mL	10.0185 mL	20.0371 mL
10mM	0.5009 mL	2.5046 mL	5.0093 mL	10.0185 mL
20mM	0.2505 mL	1.2523 mL	2.5046 mL	5.0093 mL

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.