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Isotretinoin

This product is for research use only, not for human use. We do not sell to patients.

Isotretinoin
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
2g$330Check With Us
5g$560Check With Us
10g$840Check With Us
email: [email protected]        [email protected]

Cat #: V0933 CAS #: 4759-48-2 Purity ≥ 98%

Description: Isotretinoin (Accutane; Myorisan; Zenatane; 13-cis retinoic acid) is a topically used medication approved for the treatment of severe cystic acne.

References: Layton A. The use of isotretinoin in acne. Dermatoendocrinol. 2009 May;1(3):162-9.

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Molecular Weight (MW)300.44
Molecular FormulaC20H28O2
CAS No.4759-48-2
Storage-20℃ for 3 years in powder formr
-80℃ for 2 years in solvent
Solubility In VitroDMSO: 60 mg/mL (199.7 mM)r
Water: <1 mg/mLr
Ethanol: 1 mg/mL (3.32 mM)
SMILES CodeCC(/C=C/C=C(/C=C/C1=C(CCCC(C)1C)C)C)=C/C(O)=O
Synonyms13-cis retinoic acid; Accutane; Isotretinoin; Myorisan; Zenatane
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM3.3285 mL16.6423 mL33.2845 mL66.5690 mL
5mM0.6657 mL3.3285 mL6.6569 mL13.3138 mL
10mM0.3328 mL1.6642 mL3.3285 mL6.6569 mL
20mM0.1664 mL0.8321 mL1.6642 mL3.3285 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
 
=
Concentration
 
×
Volume
 
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
 
×
 
Volume(start)
V1
 
=
 
Concentration(final)
C2
 
×
 
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.