DMOG (dimethyloxaloylglycine)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 1g | $560 | Check With Us |
| 2g | $890 | Check With Us |
| 5g | $1500 | Check With Us |
: Cat #: V0936 CAS #: 89464-63-1 Purity ≥ 98%
Description: DMOG (also called dimethyloxaloylglycine) is a novel, potent and cell permeable antagonist of α-ketoglutarate cofactor and competitive inhibitor for HIF prolyl hydroxylase with neuro- and cardioprotective effects.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 175.14 |
|---|---|
| Molecular Formula | C6H9NO5 |
| CAS No. | 89464-63-1 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 35 mg/mL (199.8 mM)r |
| Water: 35 mg/mL (199.8 mM)r | |
| Ethanol: 35 mg/mL (199.8 mM) | |
| SMILES Code | O=C(OC)CNC(C(OC)=O)=O |
| Synonyms | Dimethyloxalylglycine |
| Protocol | In Vitro | DMOG efficiently suppresses hydroxyproline synthesis in intact cells, but shows only weakly active in the microsomal system. |
|---|---|---|
| In Vivo | DMOG inhibits endogenous HIF inactivation, and induces angiogenesis in ischaemic skeletal muscles of mice. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 5.7097 mL | 28.5486 mL | 57.0972 mL | 114.1944 mL |
| 5mM | 1.1419 mL | 5.7097 mL | 11.4194 mL | 22.8389 mL |
| 10mM | 0.5710 mL | 2.8549 mL | 5.7097 mL | 11.4194 mL |
| 20mM | 0.2855 mL | 1.4274 mL | 2.8549 mL | 5.7097 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.