Fenofibrate | CAS 49562-28-9

Fenofibrate

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
100g	$450	Check With Us
200g	$700	Check With Us
500g	$1180	Check With Us

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Cat #: V0834 CAS #: 49562-28-9 Purity ≥ 98%

Description: Fenofibrate (Tricor, Procetofen, LF-178, Lipanthyl, NSC-281319; Controlip, Normalip, Secalip, durafenat, Trilipix) is a fibric acid based anti-hyperlipidemic drug of the fibrate class approved for clinical uses as a lipid-lowering agent.

References: Willson TM, et al. The PPARs: from orphan receptors to drug discovery. J Med Chem. 2000 Feb 24;43(4):527-50.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	360.83
Molecular Formula	C20H21ClO4
CAS No.	49562-28-9
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 72 mg/mL (199.5 mM)r
	Water: <1 mg/mLr
	Ethanol: 46 mg/mL (127.5 mM)
SMILES Code	CC(C)(OC1=CC=C(C(C2=CC=C(Cl)C=C2)=O)C=C1)C(OC(C)C)=O
Synonyms	Tricor, Procetofen, LF-178, Lipanthyl, Normalip, Secalip; Fenofibrate; LF 178, LF178, Controlip, durafenat

Protocol	In Vitro	Bezafibrate is an agonist of PPAR, with EC50s of 90 μM, 55 μM, 110 μM for murine PPARα, PPARγ and PPARδ, and 50 μM, 60 μM, 20 μM for human PPARα, PPARγ and PPARδ, respectively.
Protocol	In Vivo	Bezafibrate (0.5%) markedly reduces plasma lipid and glucose levels, and increases islet area in the pancreas in TallyHo mice. Bezafibrate also improves energy expenditure and metabolic flexibility. Moreover, Bezafibrate ameliorates steatosis, modifies lipid composition and increases mitochondrial mass in the liver.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.7714 mL	13.8569 mL	27.7139 mL	55.4278 mL
5mM	0.5543 mL	2.7714 mL	5.5428 mL	11.0856 mL
10mM	0.2771 mL	1.3857 mL	2.7714 mL	5.5428 mL
20mM	0.1386 mL	0.6928 mL	1.3857 mL	2.7714 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.