Roflumilast (BY217; B 9302107; BYK-20869; Daxas; Daliresp)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 2g | $1250 | Check With Us |
| 5g | $2250 | Check With Us |
| 10g | $3375 | Check With Us |
: Cat #: V0777 CAS #: 162401-32-3; Purity ≥ 98%
Description: Roflumilast (BY-217; APTA-2217; B 9302-107; BYK20869; Daxas; Daliresp) is a novel, highly potent, selective, and long-acting inhibitor of phosphodiesterase 4/PDE4 with potential anti-inflammatory activity.
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| Molecular Weight (MW) | 403.21 |
|---|---|
| Molecular Formula | C17H14Cl2F2N2O3 |
| CAS No. | 162401-32-3; |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 81 mg/mL (200.9 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: 15 mg/mL (37.2 mM) | |
| Solubility In Vivo | 30% PEG400+0.5% Tween80+5% propylene glycol: 30 mg/mL |
| SMILES Code | O=C(NC1=C(Cl)C=NC=C1Cl)C2=CC=C(OC(F)F)C(OCC3CC3)=C2 |
| Synonyms | Daliresp; BY217; BY-217; B 9302-107; BYK 20869; B-9302-107; APTA 2217, B9302-107, BY 217, BYK-20869; BYK20869; Daxas; |
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.4801 mL | 12.4005 mL | 24.8010 mL | 49.6019 mL |
| 5mM | 0.4960 mL | 2.4801 mL | 4.9602 mL | 9.9204 mL |
| 10mM | 0.2480 mL | 1.2400 mL | 2.4801 mL | 4.9602 mL |
| 20mM | 0.1240 mL | 0.6200 mL | 1.2400 mL | 2.4801 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.