MZP-54
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $2350 | Check With Us |
| 200mg | $3525 | Check With Us |
| 500mg | $5950 | Check With Us |
: Cat #: V3583 CAS #: 2010159-47-2 Purity ≥ 98%
Description: MZP-54 is a novel, potent and selective PROTAC-based degrader of BRD3/4 with a Kd of 4 nM for Brd4BD2.
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| Molecular Weight (MW) | 1036.67 |
|---|---|
| Molecular Formula | C₅₅H₆₆ClN₇O₉S |
| CAS No. | 2010159-47-2 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| SMILES Code | O=C(C1=CC=C(C2=CC3=C(N([C@H](C[C@H]3NC4=CC=C(C=C4)Cl)C)C(C)=O)C=C2)CO=C1)NCCOCCOCCOCC(N[C@H](C(N5C[C@@H](C[C@H]5C(NCC6=CC=C(C=C6)C7=C(N=CS7)C)=O)O)=O)C(C)(C)C)=O |
| Synonyms | MZP-54; MZP54; MZP 54; |
| Protocol | In Vitro | MZP-54 is a selective degrader of BRD3/4 based on PROTAC technology, with a Kd of 4 nM for Brd4BD2. MZP-54 binds to VHL-EloC-EloB protein (VCB) with a Kd of 105 ± 24 nM. MZP-54 shows an inhibitory activity against MV4;11 and HL60 cells, with pEC50s of 7.08 ± 0.05 and 6.37 ± 0.03, respectively. MZP-54 also exhibits high depletion of cMyc levels. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 0.9646 mL | 4.8231 mL | 9.6463 mL | 19.2925 mL |
| 5mM | 0.1929 mL | 0.9646 mL | 1.9293 mL | 3.8585 mL |
| 10mM | 0.0965 mL | 0.4823 mL | 0.9646 mL | 1.9293 mL |
| 20mM | 0.0482 mL | 0.2412 mL | 0.4823 mL | 0.9646 mL |
The molarity calculator equation
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The dilution calculator equation
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.