Inarigivir soproxil (SB9200)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $2650 | Check With Us |
| 250mg | $3350 | Check With Us |
| 500mg | $5025 | Check With Us |
: Cat #: V22524 CAS #: 942123-43-5 Purity ≥ 98%
Description: Inarigivir soproxil, formerly known as SB 9200, is a potent antiviral agent.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 703.62 |
|---|---|
| Molecular Formula | C25H34N7O13PS |
| CAS No. | 942123-43-5 |
| SMILES Code | O[C@@H](C[C@@H](N1C2=C(C(N)=NC=N2)N=C1)O3)[C@@H]3COP(O[C@@H]4[C@@H](CC)O[C@@H](N5CCC(NC5=O)=O)[C@@H]4OC)(SCOC(OC(C)C)=O)=O |
| Synonyms | SB 9200; SB-9200; SB9200; Inarigivir soproxil; SB 44 (dinucleotide) |
| Protocol | In Vitro | Inarigivir soproxil is an effective inhibitor of HCV replication in cell culture. The antiviral activity of Inarigivir soproxil against HCV was assessed using genotype 1 HCV replicon systems in duplicate experiments using 4 drug concentrations. Inarigivir soproxil inhibits HCV replication with EC50s of 2.2 and 1.0 µM, and EC90s of 8.0 and 6.0 µM for genotype 1A and 1B, respectively. Inarigivir soproxil (SB 9200) is a first-in-class oral modulator of innate immunity that acts via the activation of the RIG-I and NOD2 pathways. |
|---|---|---|
| In Vivo | The induction of host immune responses by pretreatment with Inarigivir soproxil (SB 9200) followed by Entecavir (ETV) resulted in antiviral efficacy that was superior to that obtained using the strategy of viral reduction with ETV followed by immunomodulation. | |
| Animal model | Woodchucks chronically infected with woodchuck hepatitis virus (WHV). |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.4212 mL | 7.1061 mL | 14.2122 mL | 28.4244 mL |
| 5mM | 0.2842 mL | 1.4212 mL | 2.8424 mL | 5.6849 mL |
| 10mM | 0.1421 mL | 0.7106 mL | 1.4212 mL | 2.8424 mL |
| 20mM | 0.0711 mL | 0.3553 mL | 0.7106 mL | 1.4212 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.