MK-0608
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $1600 | To Be Confirmed |
| 200mg | $2400 | To Be Confirmed |
| 500mg | $4050 | To Be Confirmed |
: Cat #: V17776 CAS #: 443642-29-3 Purity ≥ 99%
Description: MK-0608 (MK608; 7-deaza-2'-C-methyladenosine; 7-DMA.) is a novel and potent anti-viral agent against HCV replication with an EC50 of 0.3 μM (EC90=1.3 μM) in the subgenomic-replicon assay.
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| Molecular Weight (MW) | 280.28 |
|---|---|
| Molecular Formula | C12H16N4O4 |
| CAS No. | 443642-29-3 |
| SMILES Code | NC1=C2C(N([C@H]3[C@]([C@@H]([C@@H](CO)O3)O)(C)O)C=C2)=NC=N1 |
| Synonyms | MK0608; MK-0608; MK 0608; MK608; MK-608; MK 608; 7-deaza-2’-C-methyladenosine, 7-DMA |
| Protocol | In Vivo | Oral dosing of MK-0608 results in a potent antiviral effect. In preclinical pharmacokinetic experiments with rats, dogs, and rhesus monkeys, MK-0608 demonstrates good to excellent oral bioavailability (50 to 100%) and long plasma half-lives in dogs and rhesus macaques (9 and 14 h, respectively). |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.5679 mL | 17.8393 mL | 35.6786 mL | 71.3572 mL |
| 5mM | 0.7136 mL | 3.5679 mL | 7.1357 mL | 14.2714 mL |
| 10mM | 0.3568 mL | 1.7839 mL | 3.5679 mL | 7.1357 mL |
| 20mM | 0.1784 mL | 0.8920 mL | 1.7839 mL | 3.5679 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.