Merafloxacin

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
100mg	$750	Check With Us
250mg	$1250	Check With Us
1g	$1875	Check With Us

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Cat #: V2392 CAS #: 91188-00-0 Purity ≥ 98%

Description: Merafloxacin (CI-934; CI934; CI 934), an antibacterial belonging to the fluoroquinolone class, is a novel and potent −1 PRF (programmed -1 ribosomal frameshifting) inhibitor of SARS-CoV-2 (Severe acute respiratory syndrome coronavirus 2). It inhibits −1 PRF of SARS-CoV-2, SARS-CoV, as well as that of other beta coronaviruses. Inhibition of −1 PRF by merafloxacin impeded SARS-CoV-2 replication in Vero E6 cells, indicating that merafloxacin represents a promising lead compound for the development of a novel class of PRF-targeting antivirals.

References: [1]. Sun Y, et, al. Restriction of SARS-CoV-2 Replication by Targeting Programmed -1 Ribosomal Frameshifting In Vitro. bioRxiv. 2020 Oct 21;2020.10.21.349225.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	379.4078
Molecular Formula	C19H23F2N3O
CAS No.	91188-00-0
SMILES Code	O=C(C1=CN(CC)C2=C(C=C(F)C(N3CC(CNCC)CC3)=C2F)C1=O)O
Synonyms	CI-934; Merafloxacin; CI 934; CI934;

Protocol	In Vitro	Merafloxacin (5-80 μM) dose-dependently inhibits programmed -1 ribosomal frameshifting (-1 PRF) of SARS-CoV-2, SARS-CoV, hCoVO-C43, and hCoV-HKU1, with IC50s of 19.6 μM, 19.5 μM, 29.7 μM, and 38.6 μM, respectively.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.6357 mL	13.1784 mL	26.3569 mL	52.7137 mL
5mM	0.5271 mL	2.6357 mL	5.2714 mL	10.5427 mL
10mM	0.2636 mL	1.3178 mL	2.6357 mL	5.2714 mL
20mM	0.1318 mL	0.6589 mL	1.3178 mL	2.6357 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.