RN-18
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $950 | Check With Us |
| 250mg | $1600 | Check With Us |
| 500mg | $2400 | Check With Us |
: Cat #: V13839 CAS #: 431980-38-0 Purity ≥ 98%
Description: RN-18 is an HIV-1 Vif inhibitor.
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| Molecular Weight (MW) | 380.42 |
|---|---|
| Molecular Formula | C20H16N2O4S |
| CAS No. | 431980-38-0 |
| SMILES Code | O=C(NC1=CC=CC=C1OC)C2=CC=CC=C2SC3=CC=C([N+]([O-])=O)C=C3 |
| Synonyms | RN-18; RN 18; RN18 |
| Protocol | In Vitro | RN-18 and RN-19 exhibits potent antiviral activity in the nonpermissive H9 and CEM cells but not in MT4 or CEM-SS cells, confirming that the antiviral activity was Vif specific. RN-18 shows the greater potency (IC50=4.5 μM in CEM cells) and specificity (IC50>100 μM in MT4 cells) among the two compounds. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.6287 mL | 13.1434 mL | 26.2867 mL | 52.5735 mL |
| 5mM | 0.5257 mL | 2.6287 mL | 5.2573 mL | 10.5147 mL |
| 10mM | 0.2629 mL | 1.3143 mL | 2.6287 mL | 5.2573 mL |
| 20mM | 0.1314 mL | 0.6572 mL | 1.3143 mL | 2.6287 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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Volume
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The dilution calculator equation
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Volume(start)
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.