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Fostemsavir Tris (BMS-663068 trisaminomethane)

This product is for research use only, not for human use. We do not sell to patients.

Fostemsavir Tris (BMS-663068 trisaminomethane)
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
100mg$1250Check With Us
250mg$1850Check With Us
500mg$2775Check With Us

Cat #: V29032 CAS #: 864953-39-9 Purity ≥ 99%

Description: Fostemsavir Tris (BMS-663068 trisaminomethane or tromethamine or THAM) is the trisaminomethane salt of Fostemsavir (BMS663068; BMS-663068; Rukobia) which is an anti-HIV medication marketed in 2020.

References: Nowicka-Sans B, et al. In vitro antiviral characteristics of HIV-1 attachment inhibitor BMS-626529, the active component of the prodrug BMS-663068. Antimicrob Agents Chemother. 2012 Jul;56(7):3498-507.

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Molecular Weight (MW)704.62
Molecular FormulaC₂₉H₃₇N₈O₁₁P
CAS No.864953-39-9
SMILES CodeO=C(N1CCN(C(C2=CC=CC=C2)=O)CC1)C(C3=CN(COP(O)(O)=O)C4=C3C(OC)=CN=C4N5N=C(C)N=C5)=O.OCC(CO)(N)CO
SynonymsBMS-663068 dihydrate; BMS 663068; MS-663068 Tris; BMS-663068; BMS663068;
ProtocolIn VitroFostemsavir Tris has good antiviral activity in subjects infected with virus shown to be susceptible (IC50, <100 nM) to the agent.
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM1.4192 mL7.0960 mL14.1920 mL28.3841 mL
5mM0.2838 mL1.4192 mL2.8384 mL5.6768 mL
10mM0.1419 mL0.7096 mL1.4192 mL2.8384 mL
20mM0.0710 mL0.3548 mL0.7096 mL1.4192 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.