Ganciclovir hydrate
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 50g | $600 | Check With Us |
| 100g | $1050 | Check With Us |
| 200g | $1575 | Check With Us |
: Cat #: V19046 CAS #: 1359968-33-4 Purity ≥ 99%
Description: Ganciclovir hydrate is a novel and potent antiviral medication used to treat or prevent cytomegalovirus (CMV) infections.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 273.25 |
|---|---|
| Molecular Formula | C9H15N5O5 |
| CAS No. | 1359968-33-4 |
| SMILES Code | O=C1N=C(N)NC2=C1N=CN2COC(CO)CO.[H]O[H] |
| Synonyms | Ganciclovir; Ganciclovir Sodium; Ganciclovir Monosodium Salt; Gancyclovir; BW-759; BW 759; BW759; BIOLF-62; RS-21592; RS 21592; RS21592; brand name: Cytovene; Cymevene; Vitrasert. |
| Protocol | In Vitro | Ganciclovir (BW 759) is an acyclic deoxyguanosine analog structurally similar to acyclovir but with superior activity against CMV. The median Ganciclovir concentration required to inhibit viral replication by 50 percent is 2.15 μM versus 72 μM for acyclovir. |
|---|---|---|
| In Vivo | Ganciclovir (BW 759) (50 mg/kg; i.p.; twice a day for five injections) significantly decreases white blood cells, red blood cells and platelets in newborn mice, and can diffuse into the brain and the perilymphatic space of the inner ear. | |
| Animal model | Non-inbred Oncins France 1 (OF1) mice and albino rats non-immunized for MCMV |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.6597 mL | 18.2983 mL | 36.5965 mL | 73.1930 mL |
| 5mM | 0.7319 mL | 3.6597 mL | 7.3193 mL | 14.6386 mL |
| 10mM | 0.3660 mL | 1.8298 mL | 3.6597 mL | 7.3193 mL |
| 20mM | 0.1830 mL | 0.9149 mL | 1.8298 mL | 3.6597 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.