Edoxaban tosylate (DU-176b)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
1g	$750	Check With Us
2g	$1250	Check With Us
5g	$2110	Check With Us

: [email protected] [email protected]

Cat #: V30461 CAS #: 480449-71-6 Purity ≥ 99%

Description: Edoxaban tosylate (DU176b; DU-176; trade name Savaysa; Lixiana), the tosylate salt of edoxaban, is a marketed anticoagulant drug acting as a potent, selective, orally bioavailable and direct factor Xa inhibitor.

References: Furugohri T, et al. DU-176b, a potent and orally active factor Xa inhibitor: in vitro and in vivo pharmacological profiles. J Thromb Haemost. 2008 Sep;6(9):1542-9.

Top Publications Citing Invivochem Products

Product Catalog 2022

Guide to Product Handling

Publications Citing InvivoChem Products

Product Promise

Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	720.26
Molecular Formula	C31H38ClN7O7S2
CAS No.	480449-71-6
SMILES Code	O=C(NC1=NC=C(Cl)C=C1)C(N[C@@H]2[C@H](NC(C(S3)=NC4=C3CN(C)CC4)=O)C[C@@H](C(N(C)C)=O)CC2)=O.O=S(C5=CC=C(C)C=C5)(O)=O
Synonyms	Edoxaban tosylate; DU176b; DU-176b; DU 176b

Protocol	In Vitro	Edoxaban tosylate inhibits thrombin-induced platelet aggregation, with an IC50 of 2.90 µM. Edoxaban tosylate (1, 1 and 5 minutes respectively) prolongs PT,TT and APTT of human plasma in a concentration-dependent manner.
Protocol	In Vivo	Edoxaban tosylate (0.5, 2.5 and 12.5 mg/kg; p.o.; once) significantly and dose-dependently reduces the thrombus formation and prolongs PT.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	1.3884 mL	6.9419 mL	13.8839 mL	27.7678 mL
5mM	0.2777 mL	1.3884 mL	2.7768 mL	5.5536 mL
10mM	0.1388 mL	0.6942 mL	1.3884 mL	2.7768 mL
20mM	0.0694 mL	0.3471 mL	0.6942 mL	1.3884 mL

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.