BAMB-4(ITPKA-IN-C14)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $2150 | Check With Us |
| 200mg | $3225 | Check With Us |
| 500mg | $5440 | Check With Us |
: Cat #: V2933 CAS #: 891025-25-5 Purity ≥ 98%
Description: BAMB-4 (formerly known as ITPKA-IN-C14) is a novel and highly potent membrane-permeable inhibitor of inositol-1,4,5-trisphosphate-3-kinase A (ITPKA) with IC50 of 37 uM in ADP-Glo Assay.
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| Molecular Weight (MW) | 252.27 |
|---|---|
| Molecular Formula | C15H12N2O2 |
| CAS No. | 891025-25-5 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: ≥ 40 mg/mLr |
| Water: <1 mg/mLr | |
| Ethanol: <1 mg/mL | |
| SMILES Code | O=C(NC1=NOC2=CC=CC=C12)C3=CC=C(C)C=C3 |
| Synonyms | Bamb-4; Bamb 4; Bamb4; ITPKA-IN C14; ITPKA-INC14; ITPKA-IN-C14 |
| Protocol | In Vitro | BAMP-4 (0-30 μM) is a mixed type inhibitor with respect to ATP and InsP3 and does not only affect binding of ATP but also binding of InsP3，which affects turnover of two substrate exhibit a higher inhibition specifcity. BAMP-4 (0, 10, 20 and 40 μM) shows increased Km and decreased Vmax. BAMB-4 (100 μM, overnight) has high specificity and the high cellular uptake. BAMB-4 (40 μM) inhibits InsP3 kinase activity with an IC50 value of 20 μM. BAMB-4 (0.3-40 μM) has ITPKA inhibiton effect with an IC50 value of 37 μM. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.9640 mL | 19.8200 mL | 39.6401 mL | 79.2801 mL |
| 5mM | 0.7928 mL | 3.9640 mL | 7.9280 mL | 15.8560 mL |
| 10mM | 0.3964 mL | 1.9820 mL | 3.9640 mL | 7.9280 mL |
| 20mM | 0.1982 mL | 0.9910 mL | 1.9820 mL | 3.9640 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Concentration
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Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
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Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.