Rosiptor | CAS 782487-28-9

Rosiptor

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
100mg	$1850	To Be Confirmed
200mg	$2775	To Be Confirmed
500mg	$4680	To Be Confirmed

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Cat #: V13995 CAS #: 782487-28-9 Purity ≥ 99%

Description: Rosiptor (AQX-1125; AQX1125; AQX 1125) is an orally bioavailable and selective activator of the phosphatase SHIP1 (SH2 domain-containing inositol-5′-phosphatase 1) with potential anti-inflammatory activities.

References: Stenton GR, et al. Characterization of AQX-1125, a small-molecule SHIP1 activator: Part 1. Effects on inflammatory cell activation and chemotaxis in vitro and pharmacokinetic characterization in vivo. Br J Pharmacol. 2013 Mar;168(6):1506-18.

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Molecular Weight (MW)	321.50
Molecular Formula	C20H35NO2
CAS No.	782487-28-9
SMILES Code	C[C@]1([C@H]2CC[C@@]3(C)[C@@H](CCC3=C)[C@@H]2CN)CC[C@H](O)C[C@@H]1CO
Synonyms	Rosiptor; AQX-1125; AQX 1125; AQX1125

Protocol	In Vitro	Rosiptor (0.1-10 μM; 30 minutes) inhibits Akt activation in MOLT-4, but not in Jurkat cells.
Protocol	In Vivo	Rosiptor (10 mg/kg; p.o.) has the Cmax value of 0.830 μM and the t1/2 value of 5.2 hours. AQX-1125 also exhibits >80% oral bioavailability.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	3.1104 mL	15.5521 mL	31.1042 mL	62.2084 mL
5mM	0.6221 mL	3.1104 mL	6.2208 mL	12.4417 mL
10mM	0.3110 mL	1.5552 mL	3.1104 mL	6.2208 mL
20mM	0.1555 mL	0.7776 mL	1.5552 mL	3.1104 mL

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.