CCT007093
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $780 | Check With Us |
| 500mg | $1320 | Check With Us |
| 1g | $1980 | Check With Us |
: Cat #: V1938 CAS #: 176957-55-4 Purity ≥ 98%
Description: CCT007093, a thienylidene cyclopentanone, is a potent PPM1D (WIP1) inhibitor with IC50 of 8.4 μM.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 272.39 |
|---|---|
| Molecular Formula | C15H12OS2 |
| CAS No. | 176957-55-4 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: <1 mg/mLr |
| Water: <1 mg/mLr | |
| DMF: 3 mg/mL (11.0 mM) | |
| Solubility In Vivo | 5% DMSO+Corn oil: 1 mg/mL warmed (3.67 mM) |
| SMILES Code | O=C1/C(CC/C1=CC2=CC=CS2)=C/C3=CC=CS3 |
| Synonyms | CCT-007093; CCT007093; CCT 007093 |
| Protocol | In Vitro | CCT007093 (25 or 50 µM, 8 h) significantly increases the phosphorylation levels of mTOR at Ser2448, Ser2481 and Ser2159, and the phosphorylation levels of p70S6K (Thr389) and S6 (Ser235/236) are also up-regulated in transfected HEK293T cell line. |
|---|---|---|
| In Vivo | CCT007093 (6.4 mg/kg) enhances liver regeneration and increases the survival rate of mice following major hepatectomy. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.6712 mL | 18.3560 mL | 36.7121 mL | 73.4241 mL |
| 5mM | 0.7342 mL | 3.6712 mL | 7.3424 mL | 14.6848 mL |
| 10mM | 0.3671 mL | 1.8356 mL | 3.6712 mL | 7.3424 mL |
| 20mM | 0.1836 mL | 0.9178 mL | 1.8356 mL | 3.6712 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Concentration
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
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Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.