Pimecrolimus (ASM 981)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 500mg | $400 | In Stock |
| 1g | $650 | In Stock |
| 5g | $1645 | In Stock |
: Cat #: V1983 CAS #: 137071-32-0 Purity ≥ 98%
Description: Pimecrolimus (formerly known as ASM-981; SDZ-ASM981) is an ascomycin analog which acts as an immunomodulating agent and is used in the treatment of atopic dermatitis.
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| Molecular Weight (MW) | 810.45 |
|---|---|
| Molecular Formula | C43H68ClNO11 |
| CAS No. | 137071-32-0 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 100 mg/mL (123.4 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: 100 mg/mL (123.4 mM) | |
| SMILES Code | O=C(C(N1CCCC[C@@]1([H])C(O[C@H](/C(C)=C/[C@H]2C[C@@H](OC)[C@@H](Cl)CC2)[C@H](C)[C@@H](O)C3)=O)=O)[C@@](O4)(O)[C@H](C)C[C@H](OC)[C@@]4([H])[C@@H](OC)C[C@@H](C)C/C(C)=C/[C@@H](CC)C3=O |
| Synonyms | SDZ ASM 981; ASM-981; SDZ-ASM 981; ASM 981; SDZ-ASM-981; ASM981; ASM 981; Pimecrolimus; Pimecrolimusum; 33-epi-Chloro-33-desoxyascomycin; Brand name: Aregen; Rizan; Elidel. |
| Protocol | In Vitro | Pimecrolimus acts specifically on cells that are crucial for the effector phase of an inflammatory reaction. Pimecrolimus (SDZ-ASM 981) (100 nM) targets T-cells and mast cells and inhibits the production and release of cytokines and other inflammatory mediators, as well as the expression of signals essential for the activation of inflammatory T-lymphocytes. |
|---|---|---|
| In Vivo | Pimecrolimus (SDZ-ASM 981) (0-0.4%; topical; 10 μL once) inhibits allergic contact dermatitis in mice and pigs. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.2339 mL | 6.1694 mL | 12.3388 mL | 24.6776 mL |
| 5mM | 0.2468 mL | 1.2339 mL | 2.4678 mL | 4.9355 mL |
| 10mM | 0.1234 mL | 0.6169 mL | 1.2339 mL | 2.4678 mL |
| 20mM | 0.0617 mL | 0.3085 mL | 0.6169 mL | 1.2339 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
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V1
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Concentration(final)
C2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.