KL-1333
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $1650 | In Stock |
| 250mg | $2450 | In Stock |
| 500mg | $3675 | In Stock |
: Cat #: V5065 CAS #: 1800405-30-4 Purity ≥ 98%
Description: KL1333, a novel NAD+ modulator, is a potent, orally bioavailable and small organic molecule with the potential to treat Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS).
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 240.26 |
|---|---|
| Molecular Formula | C14H12N2O2 |
| CAS No. | 1800405-30-4 |
| Storage | -20℃ for 3 years in powder formrr |
| -80℃ for 2 years in solvent | |
| SMILES Code | O=C(C1=C2N=C(C(C)C)N1)C(C3=C2C=CC=C3)=O |
| Synonyms | KL-1333; KL 1333; KL1333; |
| Protocol | In Vitro | KL1333 is a potent modulator of the cellular levels of NAD⁺, a central co-enzyme in the cell’s energy metabolism. Elevated NAD+ levels triggers the activation of SIRT1 and AMPK, and subsequently activates PGC-1α. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 4.1622 mL | 20.8108 mL | 41.6216 mL | 83.2432 mL |
| 5mM | 0.8324 mL | 4.1622 mL | 8.3243 mL | 16.6486 mL |
| 10mM | 0.4162 mL | 2.0811 mL | 4.1622 mL | 8.3243 mL |
| 20mM | 0.2081 mL | 1.0405 mL | 2.0811 mL | 4.1622 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.