ER-000444793
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $1250 | Check With Us |
| 200mg | $1875 | Check With Us |
| 200mg | $3165 | Check With Us |
: Cat #: V29295 CAS #: 792957-74-5 Purity ≥ 99%
Description: ER-000444793 is a potent inhibitor of mitochondrial permeability transition pore (mPTP) opening.
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| Molecular Weight (MW) | 354.40 |
|---|---|
| Molecular Formula | C23H18N2O2 |
| CAS No. | 792957-74-5 |
| SMILES Code | O=C(C1=CC(NC2=C1C=CC=C2)=O)NC3=CC=CC=C3CC4=CC=CC=C4 |
| Synonyms | ER000444793; ER 000444793; ER-000444793 |
| Protocol | In Vitro | ER-000444793 is a small molecule, non-toxic mPTP inhibitor with a mechanism of action independent of CypD inhibition. ER-000444793 potently and dose-dependently inhibits Ca2+-induced mPT. ER-000444793 binds CypD, a CsA/CypD homogenous time-resolved fluorescence (HTRF) assay is used to study compound binding. Both CsA and SfA dose-dependently decrease HTRF signal, suggesting displacement of labelled CsA from rhCypD protein (CsA IC50=23 nM and SfA IC50= 5 nM). In contrast, ER-000444793 has no effect up to a concentration of 50 μM, indicating lack of displacement of labelled-CsA from rhCypD protein. Together, these data suggest the mechanism of ER-000444793 in delaying mPT is independent of CypD functional inhibition. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.8217 mL | 14.1084 mL | 28.2167 mL | 56.4334 mL |
| 5mM | 0.5643 mL | 2.8217 mL | 5.6433 mL | 11.2867 mL |
| 10mM | 0.2822 mL | 1.4108 mL | 2.8217 mL | 5.6433 mL |
| 20mM | 0.1411 mL | 0.7054 mL | 1.4108 mL | 2.8217 mL |
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Step One: Enter information below
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Average weight of animals g
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Number of animals
Step Two: Enter the in vivo formulation
%DMSO
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%
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%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
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Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
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mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.