GW604714X
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1950 | Check With Us |
| 500mg | $3250 | Check With Us |
| 1g | $4875 | Check With Us |
: Cat #: V2382 CAS #: 853953-65-8 Purity ≥ 99%
Description: GW-604714X is a novel and potent inhibitor of mitochondrial respiration.
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| Molecular Weight (MW) | 471.46 |
|---|---|
| Molecular Formula | C21H18FN5O5S |
| CAS No. | 853953-65-8 |
| Synonyms | GW-604714X; GW604714X; GW 604714X |
| Protocol | In Vitro | GW604714X inhibits the transport of 0.5 mM [14C]-l-lactate into rat red blood cells, mediated by the monocarboxylate transporter MCT1. GW604714X at 10 μM reduces the initial rate of uptake to 30% of control values. Inhibitor titrations of pyruvate-dependent respiration by heart mitochondria gave values for the concentration of inhibitor binding sites and their Ki (nM) of 56.0 nM and 0.057 nM for the GW604714X. GW604714X inhibits the mitochondrial pyruvate carrier (MPC) with Ki value <0.1 μM in direct measurement of pyruvate transport into rat liver and yeast mitochondria. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.1211 mL | 10.6054 mL | 21.2107 mL | 42.4214 mL |
| 5mM | 0.4242 mL | 2.1211 mL | 4.2421 mL | 8.4843 mL |
| 10mM | 0.2121 mL | 1.0605 mL | 2.1211 mL | 4.2421 mL |
| 20mM | 0.1061 mL | 0.5303 mL | 1.0605 mL | 2.1211 mL |
The molarity calculator equation
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The dilution calculator equation
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.