HQNO
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $750 | Check With Us |
| 500mg | $1250 | Check With Us |
| 1g | $1875 | Check With Us |
: Cat #: V2181 CAS #: 341-88-8 Purity ≥ 98%
Description: HQNO, secreted by P. aeruginosa, is a novel and potent electron transport chain inhibitor with a Kd of 64 nM for complex III.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 259.34 |
|---|---|
| Molecular Formula | C16H21NO2 |
| CAS No. | 341-88-8 |
| SMILES Code | OC1=C2C(C=CC=C2)=[N+]([O-])C(CCCCCCC)=C1 |
| Synonyms | HQNO; KF8940; KF 8940; KF-8940; Pyo II; Pyo-II; |
| Protocol | In Vitro | HQNO is a potent inhibitor of mitochondrial type II NADH:quinone oxidoreductase (NDH-2) in many species, including Yarrowia lipolytica, S. cerevisiae, Gluconobacter oxydans, T. gondii, P. falciparum, and S. aureus. HQNO targets the Q-site of NDH-2. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.8559 mL | 19.2797 mL | 38.5594 mL | 77.1188 mL |
| 5mM | 0.7712 mL | 3.8559 mL | 7.7119 mL | 15.4238 mL |
| 10mM | 0.3856 mL | 1.9280 mL | 3.8559 mL | 7.7119 mL |
| 20mM | 0.1928 mL | 0.9640 mL | 1.9280 mL | 3.8559 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.