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FX11

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FX11
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
100mg$1050To Be Comfirmed
200mg$1575To Be Comfirmed
500mg$2655To Be Comfirmed
email: [email protected]        [email protected]

Cat #: V21444 CAS #: 213971-34-7 Purity ≥ 98%

Description: FX-11 is a novel, potent and selective lactate dehydrogenase A (LDHA) inhibitor with anticancer activity.

References: EC Calvaresi. Small molecule inhibitors of lactate dehydrogenase a as an anticancer strategy. 2014.

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Molecular Weight (MW)350.41
Molecular FormulaC22H22O4
CAS No.213971-34-7
SMILES CodeO=C(C1=C2C=C(CC3=CC=CC=C3)C(C)=CC2=C(CCC)C(O)=C1O)O           
SynonymsFX 11; FX-11; FX11; LDHA Inhibitor FX11
ProtocolIn VitroFX-11 (9 μM, 24-48 h) shows activation of AMP kinase and phosphorylation of its substrate acetyl-CoA carboxylase.
In VivoFX-11 (42 µg/mouse; IP, daily for 10-14 days) inhibits P493 tumor growth.
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.8538 mL14.2690 mL28.5380 mL57.0760 mL
5mM0.5708 mL2.8538 mL5.7076 mL11.4152 mL
10mM0.2854 mL1.4269 mL2.8538 mL5.7076 mL
20mM0.1427 mL0.7134 mL1.4269 mL2.8538 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
 
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Concentration
 
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Volume
 
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Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
 
×
 
Volume(start)
V1
 
=
 
Concentration(final)
C2
 
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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.