(S)-GNE-140, the S-enantiomer of GNE-140, is a novel and potent lactate dehydrogenase (LDHA) inhibitor with less activity.

GSK2837808A is a potent, selective, and an NADH-competitive inhibitor of lactate dehydrogenase A (LDHA) with IC50s of 1.9 and 14 nM for LDHA and LDHB, respectively.

FX-11 is a novel, potent and selective lactate dehydrogenase A (LDHA) inhibitor with anticancer activity.

NHI-2 is a novel, potent, selective and cell membrane permeable inhibitor of human lactate dehydrogenase isoform A (LDH-A; IC50 values 14.7 µM and 55.8 µM in a NADH competition assay for LDH-A and LDH-B, respectively), whcih is a key enzyme necessary to sustain glycolysis, the major pathway used by many cancer cells for cell growth […]