L-778123 hydrochloride

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
250mg	$710	Check With Us
500mg	$999	Check With Us
1g	$1500	Check With Us

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Cat #: V4632 CAS #: 253863-00-2 Purity ≥ 98%

Description: L-778123 (L778123) hydrochloride is a novel and potent inhibitor of FPTase (Farnesyl:protein transferase) and GGPTase-I (geranylgeranyl:protein transferase type-I) (IC50 = 2 nM and 98 nM) with anticancer activity.

References: Lobell RB, et al. Preclinical and clinical pharmacodynamic assessment of L-778,123, a dual inhibitor of farnesyl:protein transferase and geranylgeranyl:protein transferase type-I. Mol Cancer Ther. 2002 Jul;1(9):747-758.

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Physicochemical and Storage Information
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Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	442.34
Molecular Formula	C22H21Cl2N5O
CAS No.	253863-00-2
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
SMILES Code	N#CC1=CC=C(CN2C(CN3CC(N(C4=CC=CC(Cl)=C4)CC3)=O)=CN=C2)C=C1.[H]Cl
Synonyms	L 778,123 HCl; L-778123 hydrochloride; L778123; L-778123; L 778123; L778,123; L-778,123;

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.2607 mL	11.3035 mL	22.6070 mL	45.2141 mL
5mM	0.4521 mL	2.2607 mL	4.5214 mL	9.0428 mL
10mM	0.2261 mL	1.1304 mL	2.2607 mL	4.5214 mL
20mM	0.1130 mL	0.5652 mL	1.1304 mL	2.2607 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.