BMS-214662
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $1850 | Check With Us |
| 250mg | $2650 | Check With Us |
| 500mg | $3975 | Check With Us |
: Cat #: V3486 CAS #: 195987-41-8 (free base); 195981-08-9 (HCl); 474010-58-7 (mesylate) Purity ≥ 98%
Description: BMS-214662 is a novel, potent and selective inhibitor of farnesyl transferase (FT) with potential antitumor activity and an IC50 of 1.35 nM.
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- Related Biological Data
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| Molecular Weight (MW) | 489.61 |
|---|---|
| Molecular Formula | C25H23N5O2S2 |
| CAS No. | 195987-41-8 (free base); 195981-08-9 (HCl); 474010-58-7 (mesylate) |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| SMILES Code | ARQ171; ARQ 171; ARQ-171; BMS214662; BMS214662; BMS-214662 |
| Protocol | In Vitro | BMS-214662 is over 1000-fold selective for farnesyl transferase, having IC50 values for inhibition of geranylgeranylation of Ras-CVLL and K-Ras of 1.3 and 2.3 μM, respectively. |
|---|---|---|
| In Vivo | Tumors from BMS-214662-treated mice have increased numbers of apoptotic cells as compared with the nontreated control mice. The AIs in HCT-116 tumors are increased 4-10-fold in BMS-214662-treated mice as compared with nontreated controls. BMS-214662 is significantly cytotoxic to both HCT-116 and EJ-1 tumor cells; the doses of BMS-214662 required to kill 90% of clonogenic tumor cells are approximately 75 and 100 mg/kg for HCT-116 and EJ-1 tumors. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.0424 mL | 10.2122 mL | 20.4244 mL | 40.8488 mL |
| 5mM | 0.4085 mL | 2.0424 mL | 4.0849 mL | 8.1698 mL |
| 10mM | 0.2042 mL | 1.0212 mL | 2.0424 mL | 4.0849 mL |
| 20mM | 0.1021 mL | 0.5106 mL | 1.0212 mL | 2.0424 mL |
The molarity calculator equation
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The dilution calculator equation
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Step One: Enter information below
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Step Two: Enter the in vivo formulation
%DMSO
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%ddH2O
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Method for preparing DMSO master liquid:
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,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.