Ivabradine metabolite N-Demethyl Ivabradine hydrochloride

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
100mg	$1725	To Be Confirmed
200mg	$2585	To Be Confirmed
500mg	$4360	To Be Confirmed

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Cat #: V33434 CAS #: 1246638-08-3 Purity ≥ 99%

Description: Ivabradine metabolite N-Demethyl Ivabradine hydrochloride is the N-demethylated metabolite of ivabradine (S-16257; S16257; S 16257; Corlentor; Coralan; Procoralan; Coraxan; Ivabid; Bradia), which is a cardiac pacemaker current (If) inhibitor and a medication approved in 2015 for the management of stable heart-related chest pain and heart failure.

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Molecular Weight (MW)	491.02
Molecular Formula	C26H35ClN2O5
CAS No.	1246638-08-3
SMILES Code	COC(C(OC)=C1)=CC2=C1[C@H](C2)CNCCCN3CCC(C=C(OC)C(OC)=C4)=C4CC3=O.Cl
Synonyms	N-desmethyl Ivabradine (hydrochloride); MVN 38083; MVN-38083; MVN38083

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.0366 mL	10.1829 mL	20.3658 mL	40.7315 mL
5mM	0.4073 mL	2.0366 mL	4.0732 mL	8.1463 mL
10mM	0.2037 mL	1.0183 mL	2.0366 mL	4.0732 mL
20mM	0.1018 mL	0.5091 mL	1.0183 mL	2.0366 mL

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.