Boc-Val-Cit-PAB-PNP

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
1g	$1350	To Be Confirmed
2g	$2250	To Be Confirmed
5g	$3775	To Be Confirmed

: [email protected] [email protected]

Cat #: V38433 CAS #: 870487-10-8 Purity ≥ 99%

Description: Boc-Val-Cit-PAB-PNP is a novel ADC (Antibody-Drug-Conjugation) used in ADC synthesis.

References: [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	644.67
Molecular Formula	C30H40N6O10
CAS No.	870487-10-8
Solubility In Vitro	DMSO : 100 mg/mL (155.12 mM; Need ultrasonic)
SMILES Code	O=C(OC(C)(C)C)N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=O)C(NC1=CC=C(COC(OC2=CC=C([N+]([O-])=O)C=C2)=O)C=C1)=O)=O
Synonyms	BocValCitPABPNP; Boc Val Cit PAB PNP;

Protocol	In Vitro	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	1.5512 mL	7.7559 mL	15.5118 mL	31.0236 mL
5mM	0.3102 mL	1.5512 mL	3.1024 mL	6.2047 mL
10mM	0.1551 mL	0.7756 mL	1.5512 mL	3.1024 mL
20mM	0.0776 mL	0.3878 mL	0.7756 mL	1.5512 mL

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.

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