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Fmoc-Phe-Lys(Boc)-PAB

This product is for research use only, not for human use. We do not sell to patients.

Fmoc-Phe-Lys(Boc)-PAB
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
100mg$1250Check With Us
250mg$1950Check With Us
500mg$2925Check With Us
email: [email protected]        [email protected]

Cat #: V2318 CAS #: 206133-42-8 Purity ≥ 99%

Description: Fmoc-Phe-Lys(Boc)-PAB is a novel ADC linker used in the synthesis of antibody-drug conjugates (ADC).

References: [1]. Raymond Firestone, et al. Hydrolyzable prodrugs for delivery of anticancer drugs to metastatic cells. WO1998013059A1.

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Molecular Weight (MW)720.85
Molecular FormulaC42H48N4O7
CAS No.206133-42-8
SMILES CodeO=C(NC1=CC=C(CO)C=C1)[C@H](CCCCNC(OC(C)(C)C)=O)NC([C@H](CC2=CC=CC=C2)NC(OCC3C4=C(C5=C3C=CC=C5)C=CC=C4)=O)=O
SynonymsFmoc-Phe-Lys(Boc)-PAB;
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM1.3873 mL6.9363 mL13.8725 mL27.7450 mL
5mM0.2775 mL1.3873 mL2.7745 mL5.5490 mL
10mM0.1387 mL0.6936 mL1.3873 mL2.7745 mL
20mM0.0694 mL0.3468 mL0.6936 mL1.3873 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
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Volume(start)
V1
 
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Concentration(final)
C2
 
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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.