Mc-Val-Ala-PAB

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
250mg	$600	Check With Us
500mg	$950	Check With Us
1g	$1425	Check With Us

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Cat #: V25127 CAS #: 1870916-87-2 Purity ≥ 99%

Description: Mc-Val-Ala-PAB is a useful linker to make antibody-drug-conjugate (ADC) for targeting drug delivery.

References: [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	486.56
Molecular Formula	C25H34N4O6
CAS No.	1870916-87-2
SMILES Code	O=C(N[C@@H](C(C)C)C(N[C@@H](C)C(NC(C=C1)=CC=C1CO)=O)=O)CCCCCN2C(C=CC2=O)=O
Synonyms	Mc-Val-Ala-PAB; ACD linker; Mc-Val-Ala-PAB-OH;

Protocol	In Vitro	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.0552 mL	10.2762 mL	20.5524 mL	41.1049 mL
5mM	0.4110 mL	2.0552 mL	4.1105 mL	8.2210 mL
10mM	0.2055 mL	1.0276 mL	2.0552 mL	4.1105 mL
20mM	0.1028 mL	0.5138 mL	1.0276 mL	2.0552 mL

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.

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