DBCO-acid

This product is for research use only, not for human use. We do not sell to patients.

DBCO-acid
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
500mg$550Check With Us
1g$900Check With Us
5g$2400Check With Us

Cat #: V19218 CAS #: 1353016-70-2 Purity ≥ 99%

Description: DBCO-acid is a non-activated and cleavable building block and ADC linker that can add minimal spacer to modified molecules such as in the synthesis of ADC linker DBCO-NHS ester. Reference: Production of site-specific antibody-drug conjugates using optimized non-natural amino acids in a cell-free expression system. Bioconjug Chem. 2014 Feb 19;25(2):351-61.

References: [1]. Zimmerman ES, et al. Production of site-specific antibody-drug conjugates using optimized non-natural amino acids in a cell-free expression system. Bioconjug Chem. 2014 Feb 19;25(2):351-61.

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Product Promise

Promise
Molecular Weight (MW)305.33
Molecular FormulaC19H15NO3
CAS No.1353016-70-2
Solubility In VitroDMSO : 100 mg/mL (327.51 mM; Need ultrasonic)
SMILES CodeO=C(CCC(O)=O)N1CC2=C(C=CC=C2)C#CC3=C1C=CC=C3 
SynonymsDM1; DM-1; DM 1; DM1 [Maytansinoid]; Maytansinoid DM 1; DM1 Compound; UNII-DDZ29HGH0E; maytansine, Mertansine; emtansine; Maytansinoid DM1; Maytansinoid DM-1;
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM3.2751 mL16.3757 mL32.7514 mL65.5029 mL
5mM0.6550 mL3.2751 mL6.5503 mL13.1006 mL
10mM0.3275 mL1.6376 mL3.2751 mL6.5503 mL
20mM0.1638 mL0.8188 mL1.6376 mL3.2751 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.