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Val-Lys(Boc)-PAB

This product is for research use only, not for human use. We do not sell to patients.

Val-Lys(Boc)-PAB
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
250mg$1250Check With Us
500mg$1950Check With Us
1g$2925Check With Us
email: [email protected]        [email protected]

Cat #: V2314 CAS #: 1432969-86-2 Purity ≥ 99%

Description: Val-Lys(Boc)-PAB is a novel ADC linker which was used to prepare camptothecin peptide conjugates as antitumor agents (WO 2019195665).

References: [1]. Geoffrey Alan Pietersz. Immunomodulatory conjugates. WO2013067597A1 (compound PEG-A)

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Molecular Weight (MW)450.57
Molecular FormulaC23H38N4O5
CAS No.1432969-86-2
SMILES CodeCC(C)(OC(NCCCC[C@@H](C(NC1=CC=C(CO)C=C1)=O)NC([C@H](C(C)C)N)=O)=O)C
SynonymsVal-Lys(Boc)-PAB;
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.2194 mL11.0971 mL22.1941 mL44.3882 mL
5mM0.4439 mL2.2194 mL4.4388 mL8.8776 mL
10mM0.2219 mL1.1097 mL2.2194 mL4.4388 mL
20mM0.1110 mL0.5549 mL1.1097 mL2.2194 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
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Volume(start)
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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.