SPDB crosslinker

This product is for research use only, not for human use. We do not sell to patients.

SPDB crosslinker
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
250mg$1000To Be Confirmed
500g$1500To Be Confirmed
1g$2250To Be Confirmed

Cat #: V5622 CAS #: 115088-06-7 Purity ≥ 98%

Description: SPDB is useful heterobifunctional cross-linker, which is widely used to conjugate a small molecule drug to a targeted carrier (such as antibody, enzyme, protein and polymer). SPDB can be used to make ADC (antobody drug conjugate. Conjugated to antibodies utilizing anti-EGFR-SPDB-DM4 has been widely used.

References: [1]. Widdison WC et al. Development of Anilino-Maytansinoid ADCs that Efficiently Release Cytotoxic Metabolitesin Cancer Cells andInduce High Levels of Bystander Killing. Bioconjug Chem, 2015 Nov 18, 26(11):2261-78.

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Product Promise

Promise
Molecular Weight (MW)326.39
Molecular FormulaC13H14N2O4S2
CAS No.115088-06-7
SMILES CodeO=C(ON1C(CCC1=O)=O)CCCSSC2=NC=CC=C2
SynonymsSPDB disulfide heterobifunctional cross-linker; SPDB;
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM3.0638 mL15.3191 mL30.6382 mL61.2764 mL
5mM0.6128 mL3.0638 mL6.1276 mL12.2553 mL
10mM0.3064 mL1.5319 mL3.0638 mL6.1276 mL
20mM0.1532 mL0.7660 mL1.5319 mL3.0638 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.