Mc-Val-Cit-PABC-PNP

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
250mg	$1450	To Be Confirmed
500mg	$2450	To Be Confirmed
1g	$3675	To Be Confirmed

: [email protected] [email protected]

Cat #: V5176 CAS #: 159857-81-5 Purity ≥ 98%

Description: Mc-Val-Cit-PABC-PNP (Mc-Val-Cit-PABC-PNP) is a cathepsin cleavable ADC peptide linker used in the synthesis of antibody-drug conjugates (ADCs). The mechanism is like this: the Val-Cit will specifically be cleaved by catepsin B as this enzyme is only present in the lysosome, the ADC warhead/payload (the drug) will be released in the cell. The Azido group will react with DBCO, BCN or other Alkyne groups through click chemistry. The hydrophilic PEG spacer increases solubility in aqueous media.

References: [1]. Che-Leung Law et al. Anti-cd70 antibody-drug conjugates and their use for the treatment of cancer and immune disorders.Patent WO2005081711A2.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	572.65
Molecular Formula	C28H40N6O7
CAS No.	159857-81-5
Storage	-20℃ for 3 years in powder formrrr
Storage	-80℃ for 2 years in solvent
SMILES Code	O=C([C@@H](NC([C@@H](NC(CCCCCN1C(C=CC1=O)=O)=O)C(C)C)=O)CCCNC(N)=O)NC2=CC=C(C=C2)COC(OC3=CC=C(C=C3)[N+]([O-])=O)=O
Synonyms	Maleimidocaproyl-L-valine-L-citrulline-p-aminobenzyl alcohol p-nitrophenyl carbonate; MC-Val-Cit-PAB-PNP; Mc-Val-Cit-PABC-PNP; Mc-Val-Cit-PAB

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	1.7463 mL	8.7313 mL	17.4627 mL	34.9253 mL
5mM	0.3493 mL	1.7463 mL	3.4925 mL	6.9851 mL
10mM	0.1746 mL	0.8731 mL	1.7463 mL	3.4925 mL
20mM	0.0873 mL	0.4366 mL	0.8731 mL	1.7463 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.