FRAX1036
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1345 | Check With Us |
| 500mg | $2245 | Check With Us |
| 1g | $3365 | Check With Us |
: Cat #: V21361 CAS #: 1432908-05-8 Purity ≥ 99%
Description: FRAX1036 (FRAX-1036; FRAX 1036) is a selective p21-activated kinase 1 (PAK1) inhibitor with potential anticancer activity.
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- Related Biological Data
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| Molecular Weight (MW) | 518.05 |
|---|---|
| Molecular Formula | C28H32ClN7O |
| CAS No. | 1432908-05-8 |
| Protocol | In Vitro | FRAX1036 is a PAK inhibitor with Kis of 23.3 nM, 72.4 nM, and 2.4 μM for PAK1, PAK2 and PAK4, respectively. FRAX1036 (2.5 μM) incombination with docetaxel alters stathmin phosphorylation, induces the apoptotic marker cleaved PARP and increases kinetics of apoptosis in MDA-MB-175 and HCC2911 cells; also alters microtubule organization, mitosis and cell fate in U2OS cells. Moreover, FRAX1036 shows significantly effective inhibition on U2OS cells |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.9303 mL | 9.6516 mL | 19.3032 mL | 38.6063 mL |
| 5mM | 0.3861 mL | 1.9303 mL | 3.8606 mL | 7.7213 mL |
| 10mM | 0.1930 mL | 0.9652 mL | 1.9303 mL | 3.8606 mL |
| 20mM | 0.0965 mL | 0.4826 mL | 0.9652 mL | 1.9303 mL |
The molarity calculator equation
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The dilution calculator equation
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.