Elafibranor
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $350 | In Stock |
| 250mg | $550 | In Stock |
| 500mg | $825 | In Stock |
: Cat #: V3186 CAS #: 923978-27-2 Purity ≥ 98%
Description: Elafibranor (formerly GFT505) is a dual agonist of the PPARα/δ (peroxisome proliferator-activated receptor-α and -δ) with EC50 values of 45 and 175 nM, respectively.
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- Physicochemical and Storage Information
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- Related Biological Data
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| Molecular Weight (MW) | 384.49 |
|---|---|
| Molecular Formula | C22H24O4S |
| CAS No. | 923978-27-2 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: >70 mg/mLr |
| Water: < 1 mg/mLr | |
| Ethanol: >70 mg/mL | |
| SMILES Code | CC(C)(OC1=C(C)C=C(/C=C/C(C2=CC=C(SC)C=C2)=O)C=C1C)C(O)=O |
| Synonyms | GFT-505; GFT505; Elafibranor; GFT 505; |
| Protocol | In Vitro | Elafibranor (GFT505) is being developed as a dual PPAR-α/PPAR-δ agonist for the treatment of T2DM and non-alcoholic fatty liver disease. Elafibranor has an active metabolite, GFT1007, and both have potent agonist activity for PPAR-α and to a lesser extent for PPAR-δ |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.6008 mL | 13.0042 mL | 26.0085 mL | 52.0170 mL |
| 5mM | 0.5202 mL | 2.6008 mL | 5.2017 mL | 10.4034 mL |
| 10mM | 0.2601 mL | 1.3004 mL | 2.6008 mL | 5.2017 mL |
| 20mM | 0.1300 mL | 0.6502 mL | 1.3004 mL | 2.6008 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.