GW1929
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 500mg | $1750 | To Be Confirmed |
| 1g | $2625 | To Be Confirmed |
| 200mg | $1150 | To Be Confirmed |
: Cat #: V4936 CAS #: 196808-24-9 Purity ≥ 98%
Description: GW1929 is a novel, potent and selective PPAR-γ agonist with a pKi of 8.84 for human PPAR-γ, and pEC50s of 8.56 and 8.27 for human PPAR-γ and murine PPAR-γ, respectively.
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| Molecular Weight (MW) | 495.57 |
|---|---|
| Molecular Formula | C30H29N3O4 |
| CAS No. | 196808-24-9 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent |
| Protocol | In Vitro | GW1929 is a potent PPAR-γ activator against human PPAR-γ, PPAR-α and PPAR-δ pKi The pEC of 8.84, < 5.5 and < 6.5, respectively, was pE for human PPAR-γ and murine PPAR-γ50 8.56 and 8.27, respectively |
|---|---|---|
| In Vivo | GW1929 (0.5, 1, 5 mg/kg, orally) significantly reduced non-fasting plasma glucose levels in Zucker diabetic obese (ZDF) rats after 14 days of treatment and had anti-lipolytic effects. GW1929 (1,5 mg/kg, po) increases glucose-stimulated β-cell insulin secretion in ZDF rats |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.0179 mL | 10.0894 mL | 20.1788 mL | 40.3576 mL |
| 5mM | 0.4036 mL | 2.0179 mL | 4.0358 mL | 8.0715 mL |
| 10mM | 0.2018 mL | 1.0089 mL | 2.0179 mL | 4.0358 mL |
| 20mM | 0.1009 mL | 0.5045 mL | 1.0089 mL | 2.0179 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Concentration
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Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.