Colchicine

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
2g	$100	Check With Us
5g	$200	Check With Us
10g	$300	Check With Us

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Cat #: V3117 CAS #: 64-86-8 Purity ≥ 98%

Description: Colchicine (Colchicina; Condylon; Colsaloid; Colchicinum) is a mitotic/tubulin inhibitor that inhibits microtubule polymerization (also called microtubule disrupting agent or tubulin inhibitor) with potential anticancer and anti-inflammatory effects.

References: Bonfoco E, et al. Colchicine induces apoptosis in cerebellar granule cells. Exp Cell Res. 1995 May;218(1):189-200.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	399.44
Molecular Formula	C22H25NO6
CAS No.	64-86-8
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: ~80 mg/mL (200.3 mM)r
	Water: ~80 mg/mL (200.3 mM)r
	Ethanol: ~80 mg/mL (200.3 mM)
SMILES Code	CC(N[C@H](C1=C2)CCC3=CC(OC)=C(OC)C(OC)=C3C1=CC=C(OC)C2=O)=O
Synonyms	Colchicina; Condylon; Colsaloid; Colchicine; Colchicinum

Protocol	In Vitro	Exposure to 1μM Colchicine, a microtubule disrupting agent, triggered apoptosis in rat cerebellar granule cells (CGC). Colchicine treatment also causes alterations in Ca2+ responses to chemical depolarization and a moderate, but progressive, increase in the resting intracellular Ca2+ concentration

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.5035 mL	12.5175 mL	25.0350 mL	50.0701 mL
5mM	0.5007 mL	2.5035 mL	5.0070 mL	10.0140 mL
10mM	0.2504 mL	1.2518 mL	2.5035 mL	5.0070 mL
20mM	0.1252 mL	0.6259 mL	1.2518 mL	2.5035 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.