Deoxypodophyllotoxin
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $1850 | Check With Us |
| 250mg | $2960 | Check With Us |
| 500mg | $4440 | Check With Us |
: Cat #: V32040 CAS #: 19186-35-7 Purity ≥ 99%
Description: Deoxypodophyllotoxin is a novel and potent analogue of podophyllotoxin
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 398.41 |
|---|---|
| Molecular Formula | C22H22O7 |
| CAS No. | 19186-35-7 |
| Protocol | In Vitro | Deoxypodophyllotoxin (25-75 nM; 6-48 hours) increases the percentage of early apoptotic cell population from 2.05 to 5.62 and 18.49% for 24 h and 48 h, respectively |
|---|---|---|
| In Vivo | Deoxypodophyllotoxin (intravenously injected; 5, 10, and 20 mg/kg; 3 times a week; 28 days) suppresses the tumors in a dose-dependent manner, the growth of tumors is inhibited by 22.19%, 47.91% and 50.93% with DPT at 5, 10 and 20 mg/kg, respectively. | |
| Animal model | Xenograft model of gastric cancer in nude mice with SGC-7901 cells | |
| Dosages | 5, 10, and 20 mg/kg | |
| Administration | Intravenously injected; 5, 10, and 20 mg/kg; 3 times a week; 28 days |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.5100 mL | 12.5499 mL | 25.0998 mL | 50.1995 mL |
| 5mM | 0.5020 mL | 2.5100 mL | 5.0200 mL | 10.0399 mL |
| 10mM | 0.2510 mL | 1.2550 mL | 2.5100 mL | 5.0200 mL |
| 20mM | 0.1255 mL | 0.6275 mL | 1.2550 mL | 2.5100 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.